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Brominated compounds are more toxic systemi-cally and locally than chlorinated compounds while fluorinereplacement of the chlorine may decrease the observed tox-icity. The ATBC study suggested that highconsumption of coffee might reduce the risk of cerebralinfarction (but not intracerebral or subarachnoid hemor-rhage) among male smokers (Larsson et al., 2008a). The sulphated polymers are com-posed of a central core protein attached to disaccharide branches deriving fromsulphate monosaccharides or glycosaminoglycans (GAGs)
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