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Furthermore, the geriatri-cian and geriatric neurologist should ensure that risk fac-tors for the development of disabling visual impairmentare appropriately addressed, that primary and second-ary prevention is undertaken when appropriate (includ-ing use of antioxidants and mineral supplements forsecondary prevention of severe macular degeneration),and that rehabilitation approaches are utilized that maxi-mize residual visual function (including use of accessiblepublishing and adaptive low-vision aids). Recently, a ver-sion of this mode has been implemented on theAvea ventilator (CareFusion, San Diego, CA),the Fabian (Acutronic, Hirzel, Switzerland), andthe SLE 5000 (SLE Limited, South Croydon,England), but there are no published studies asyet regarding the performance or effectiveness ofthese volume guarantee or also called volume-targeted modes as implemented on these device.Volume guarantee may be combined with any ofthe standard ventilator modes (A/C, SIMV, andpressure support ventilation (PSV)). Due to itsconcavity, light from the otoscope reflects off the tympanicmembrane as a triangular cone of light (light reflex) thatradiates anteriorly and inferiorly from the umbo (Fig

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However, as these trials expandedusing increasing numbers of metastatic melanoma patients it was apparent that only one-thirdof these patients responded and in some cases, suffered from the side effects of IL-2 therapy(Rosenberg 1994).
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